抗人HLA-A,B,C抗体（W6/32）产品介绍

品牌名称：Anti-Human HLA-A,B,C Antibody (W6/32) (FHM00110)

产品描述

Z6·尊龙凯时的W6/32单克隆抗体专门针对人类主要组织相容性复合体（MHC）I类分子，即HLA-A、B、C。MHCI类抗原与β2-微球蛋白相互作用，并在所有人类有核细胞中广泛表达。该抗体在细胞介导的免疫反应及肿瘤监测中扮演关键角色。W6/32抗体能够识别HLA-A、B和C位点的共享非多态性表位，并成功免疫沉淀43kDa及11-12kDa链。该抗体还与狒狒、恒河猴和食蟹猴有交叉反应。

产品详情

名称：Anti-Human HLA-A,B,C Antibody (W6/32) (FHM00110)
货号：FHM00110
种属反应性：Human
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
偶联物：Unconjugated
浓度：6mg/ml
内毒素水平：请联系实验室获取此信息
纯度：95%（由SDS-PAGE确定）
纯化方式：由细胞培养上清用Protein A/G纯化
克隆号：W6/32
应用：ELISA, FCM, ICC, IHC-Fr, IP, WB
状态：液体
保存溶液：001M PBS, pH 7.4
稳定性和存储：使用手动解冻的冰箱，避免重复冻融循环。短期（1-2周）在4°C保存，长期在-20°C保存12个月及-80°C保存。

参考文献

• Mapping of the monoclonal antibody W6/32: sensitivity to the amino terminus of beta2-microglobulin PMID: 9672158
• The Structural Basis for Recognition of Human Leukocyte Antigen Class I Molecules by the Pan-HLA Antibody W6/32 PMID: 39093013
• Residue 3 of beta2-microglobulin affects binding of class I MHC molecules by the W6/32 antibody PMID: 10079295
• Expression of the W6/32 HLA epitope by cells of rat, mouse, human and other species: critical dependence on the interaction of specific MHC heavy chains with human or bovine beta2-microglobulin PMID: 2443365
• Biotinylation of class I MHC molecules abrogates recognition by W6/32 antibody PMID: 10395109
• A novel strategy of c-myc oncogene in NK activity regulation not related to the W6/32 MHC class-I epitope PMID: 7516924
• Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C antigens PMID: 87477
• Quantitative analysis of platelet surface HLA by W6/32 anti-HLA monoclonal antibody PMID: 3742047
• Monomorphic anti-HLA monoclonal antibody (W6/32) recognizes polymorphic H-2 heavy-chain determinants exposed by association with bovine or human but not murine beta2-microglobulin PMID: 3316135
• Enhancement of tumor cell lysis by natural killer cells after blocking of HLA-monohorphic determinant using F(ab')2 fragment of W6/32 PMID: 9544438

详情请咨询Z6·尊龙凯时中国授权总代理——武汉佰乐博生物技术有限公司。作为法国Antibodysystem品牌在亚洲区的授权总代理，我们提供近3万种蛋白、抗体等核心生命科学试剂，致力于为生命科学科研工作者提供专业、全面、可靠的试剂产品。

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